Journal article

Self-rated health, epigenetic ageing, and long-term mortality in older Australians

DL Li, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué

Geroscience | SPRINGER | Published : 2024

DOI: 10.1007/s11357-024-01211-2

Abstract

Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidence found that it is a strong predictor of mortality, although the underlying mechanism is poorly understood. Epigenetic age is an objective, emerging biomarker of health, estimated using DNA methylation data at hundreds of sites across the genome. This study aimed to assess the overlap and interaction between SRH and epigenetic ageing in predicting mortality risk. We used DNA methylation data from 1059 participants in the Melbourne Collaborative Cohort Study (mean age: 69 years) to calculate three age-adjusted measures of epigenetic ageing: GrimAge, PhenoAge, and DunedinPA..

View full abstract

University of Melbourne Researchers

Allison Hodge Author

Melissa Southey Author

Graham Giles Author

Roger Milne Author

Related Projects (6)

Methylation of DNA and colorectal cancer

Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essen..

A PROSPECTIVE STUDY OF THE INFLUENCE OF HEALTH - RELATED LIFESTYLE FACTORS ON DNA METHYLATION

It is known that DNA methylation can lead to disease. We aim to discover what causes DNA methylation to change. This could open the way for ..

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

METHYLATION AS A RISK FACTOR FOR PROSTATE CANCER

DNA methylation is a process that plays a critical role throughout life by altering the expression of genes. We aim to investigate the poten..

METHYLATION AND THE RISK OF UROTHELIAL CELL CANCER

Why don’t we run prevention programs for urinary tract cancers like we do for others? It’s because we don’t know which lifestyle factors, ex..

Epidemiology of chronic disease, health interventions and DNA studies

Grants

Awarded by VicHealth

Funding Acknowledgements

No Statement Available

Citation metrics

Keywords

Geriatrics & Gerontology

32 Biomedical and Clinical Sciences

Epigenetic Ageing

3202 Clinical Sciences

31 Biological Sciences

Life Sciences & Biomedicine

Health Disparities and Racial Or Ethnic Minority Health Research

Self-Rated Health

Clinical Research

3 Good Health and Well Being

Minority Health

Science & Technology

Health Disparities

All-Cause Mortality